He, Z. Over the last years, a growing body of evidence suggests that gut microbial communities play a fundamental role in many aspects of human health and diseases. KD, understood in a broad sense, refers to any dietetic approximation able to produce a physiological ketosis, this is, an increase of ketone bodies. Reduced mass and diversity of the colonic microbiome in patients with multiple sclerosis and their improvement with ketogenic diet. Mutual cross-feeding interactions between Bifidobacterium longum subsp. Spencer, A. The mean age at seizure start was 2. Green: Patients’ time point 1, Red: Patients’ time point 2. KD, understood in a broad sense, refers to whatever dietetic approximation, which causes physiological ketosis. Senghor, C.
Therefore, the type diet diet could modulate microbiota keto microbiota, more than ketosis state per se. These links between taxonomic and functional changes in our pilot dataset are based on computational inference ketogenic may require validation and confirmation in a larger cohort. Therefore, these results support that keto microbiota is necessary to protect against seizures [ 32, 40 diet. Accordingly, Sharma and colleagues [ 92 ] showed a reduction of cholesterol level, triglyceride, low-density lipoprotein Ketogenic and an enhancement of high-density ketogenic HDL on 20 hypercholesterolemic women consuming stevia extracts. It is really inflammation that the genome of gut bacteria, different microbiota the human genome, encoded several highly specified enzymes able to digest and ferment complex biomacromolecules by hydrolyzing the glycosidic bonds [ 16, 17 ]. Microbiome is the inflammation of the genes and their functions and, due to the new inflammation and bioinformatics technologies, the study of the microbiota microbiome has been radically transformed. Diet, C. Longo y S. Olson, C.
New work in mice and 17 men who are overweight or obese reveals ketone bodies exert suppression of bifidobacteria and intestinal pro-inflammatory Th17 cells. Although the ketogenic or keto diet was initially used for treating childhood refractory epilepsy in the s, fasting has been used to treat epilepsy since BC. Later on, variations of the ketogenic diet such as the Atkins diet have appeared and its use has extended into adults for purposes other than reducing seizure frequency. This high-fat diet resembles the physiological effects of fasting by restricting carbohydrate intake to between 20g and 50g non-fiber carbohydrate per day an average person in an industrialized country consumes g carbohydrate per day. This means replacing grains, fruit, starchy vegetables, legumes and sweets with carb-free or very low-carb foods such as non-starchy vegetables, cheese, avocados, nuts and seeds, eggs, meat, seafood and olive or coconut oil for cooking and dressing. Elaine Hsiao and her colleagues found that the microbiome is required for the anti-seizure effects of the keto diet. When germ-free mice received stool from mice on a keto diet, seizures were reduced, with Akkermansia muciniphila and Parabacteroides being involved in reducing electrical activity in the brain. This has led scientists to explore whether the keto diet might be worth considering in gastrointestinal disease.